Interactions micro-organismes et voies aériennes distales : spécificités pédiatriques
Identifieur interne : 000281 ( France/Analysis ); précédent : 000280; suivant : 000282Interactions micro-organismes et voies aériennes distales : spécificités pédiatriques
Auteurs : J. De Blic [France] ; J. Brouard [France] ; A. Vabret [France] ; A. Deschildre [France]Source :
- Revue Des Maladies Respiratoires [ 0761-8425 ] ; 2017.
Abstract
Le spectre des virus à tropisme respiratoire s’élargit et des maladies émergentes sont régulièrement décrites depuis une quinzaine d’années. L’origine de ces virus respiratoires émergents peut être zoonotique (par franchissement de barrière d’espèce, après mutations pour les virus à ARN tels que les virus aviaires influenza de type A ou les coronavirus), ou liée aux nouvelles techniques d’identification (métapneumovirus, bocavirus). Les relations entre bronchiolite et asthme sont désormais mieux appréhendées grâce au suivi prospectif de cohortes de nouveau-nés. Le rôle des rhinovirus devient prépondérant par rapport au virus respiratoire syncytial. L’identification de facteurs de prédispositions immunologiques, fonctionnelles, atopiques et génétiques, pour la survenue de l’asthme après une infection à rhinovirus suggère que l’infection virale révèle un terrain prédisposé plutôt qu’elle est à l’origine de l’asthme. Le rôle des bactéries dans l’histoire naturelle de l’asthme commence également à être mieux cerné. Les résultats de la cohorte danoise COPSAC ont montré la fréquence des identifications bactériennes au cours des épisodes sifflants avant 3 ans, ainsi que l’impact de la colonisation bactérienne à l’âge de un mois sur la survenue de l’asthme à l’âge de 5 ans. Le rôle des infections bactériennes dans l’asthme sévère du jeune enfant est également discuté.
Url:
DOI: 10.1016/j.rmr.2016.02.012
PubMed: 28262277
PubMed Central: 7125672
Affiliations:
- France
- Basse-Normandie, Hauts-de-France, Nord-Pas-de-Calais, Région Normandie, Île-de-France
- Caen, Lille, Paris
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000E73
- to stream Pmc, to step Curation: 000E73
- to stream Pmc, to step Checkpoint: 000221
- to stream Ncbi, to step Merge: 001C43
- to stream Ncbi, to step Curation: 001C43
- to stream Ncbi, to step Checkpoint: 001C43
- to stream Main, to step Merge: 000691
- to stream Main, to step Curation: 000689
- to stream Main, to step Exploration: 000689
- to stream France, to step Extraction: 000281
Links to Exploration step
PMC:7125672Le document en format XML
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Deschildre</name><affiliation wicri:level="3"><nlm:aff id="aff0020">Unité de pneumologie-allergologie pédiatrique, pôle enfant, hôpital Jeanne-de-Flandre, CHRU de Lille, avenue Avinée, 59037 Lille cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité de pneumologie-allergologie pédiatrique, pôle enfant, hôpital Jeanne-de-Flandre, CHRU de Lille, avenue Avinée, 59037 Lille cedex</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author></analytic><series><title level="j">Revue Des Maladies Respiratoires</title><idno type="ISSN">0761-8425</idno><idno type="eISSN">1776-2588</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Résumé</title><p>Le spectre des virus à tropisme respiratoire s’élargit et des maladies émergentes sont régulièrement décrites depuis une quinzaine d’années. L’origine de ces virus respiratoires émergents peut être zoonotique (par franchissement de barrière d’espèce, après mutations pour les virus à ARN tels que les virus aviaires influenza de type A ou les coronavirus), ou liée aux nouvelles techniques d’identification (métapneumovirus, bocavirus). Les relations entre bronchiolite et asthme sont désormais mieux appréhendées grâce au suivi prospectif de cohortes de nouveau-nés. Le rôle des rhinovirus devient prépondérant par rapport au virus respiratoire syncytial. L’identification de facteurs de prédispositions immunologiques, fonctionnelles, atopiques et génétiques, pour la survenue de l’asthme après une infection à rhinovirus suggère que l’infection virale révèle un terrain prédisposé plutôt qu’elle est à l’origine de l’asthme. Le rôle des bactéries dans l’histoire naturelle de l’asthme commence également à être mieux cerné. Les résultats de la cohorte danoise COPSAC ont montré la fréquence des identifications bactériennes au cours des épisodes sifflants avant 3 ans, ainsi que l’impact de la colonisation bactérienne à l’âge de un mois sur la survenue de l’asthme à l’âge de 5 ans. Le rôle des infections bactériennes dans l’asthme sévère du jeune enfant est également discuté.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Tumpey, T M" uniqKey="Tumpey T">T.M. Tumpey</name></author><author><name sortKey="Basler, C F" uniqKey="Basler C">C.F. Basler</name></author><author><name sortKey="Aguilar, P V" uniqKey="Aguilar P">P.V. Aguilar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Claas, E C" uniqKey="Claas E">E.C. Claas</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. 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Zhang</name></author><author><name sortKey="Illing, R" uniqKey="Illing R">R. Illing</name></author><author><name sortKey="Hui, C K" uniqKey="Hui C">C.K. Hui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van De Kant, K D" uniqKey="Van De Kant K">K.D. van de Kant</name></author><author><name sortKey="Klaassen, E M" uniqKey="Klaassen E">E.M. Klaassen</name></author><author><name sortKey="Van Aerde, K J" uniqKey="Van Aerde K">K.J. van Aerde</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li></country><region><li>Basse-Normandie</li><li>Hauts-de-France</li><li>Nord-Pas-de-Calais</li><li>Région Normandie</li><li>Île-de-France</li></region><settlement><li>Caen</li><li>Lille</li><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="De Blic, J" sort="De Blic, J" uniqKey="De Blic J" first="J." last="De Blic">J. De Blic</name></region><name sortKey="Brouard, J" sort="Brouard, J" uniqKey="Brouard J" first="J." last="Brouard">J. Brouard</name><name sortKey="Deschildre, A" sort="Deschildre, A" uniqKey="Deschildre A" first="A." last="Deschildre">A. Deschildre</name><name sortKey="Vabret, A" sort="Vabret, A" uniqKey="Vabret A" first="A." last="Vabret">A. Vabret</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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